1494684-33-1
1494684-33-1 structure
- Name: CYH33 methanesulfonate
- Chemical Name: CYH33 methanesulfonate
- CAS Number: 1494684-33-1
- Molecular Formula: C25H33F3N8O8S2
- Molecular Weight: 694.702
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2020-01-20 11:42:56
- Modify Date: 2024-04-05 19:17:18
-
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical
| Name | CYH33 methanesulfonate |
|---|
| Description | CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively; also displays little to no activity against more than 300 kinases; inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.; shows significant efficacy to inhibit the growth of SKOV-3 xenograft. Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Haoyue Xiang, et al. Abstract LB-268, AACR, 2018. View Related Products by Target PI3K Solid Tumors |
| Molecular Formula | C25H33F3N8O8S2 |
|---|---|
| Molecular Weight | 694.702 |