Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: NITD-916
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


1614262-83-7

1614262-83-7 structure
1614262-83-7 structure
  • Name: NITD-916
  • Chemical Name: NITD-916
  • CAS Number: 1614262-83-7
  • Molecular Formula: C20H25NO2
  • Molecular Weight: 311.425
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2020-01-12 11:59:50
  • Modify Date: 2024-01-12 07:14:21
  • NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.

Name NITD-916
Description NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
References References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. 2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136. View Related Products by Target Bacterial
Molecular Formula C20H25NO2
Molecular Weight 311.425