1614262-83-7
1614262-83-7 structure
- Name: NITD-916
- Chemical Name: NITD-916
- CAS Number: 1614262-83-7
- Molecular Formula: C20H25NO2
- Molecular Weight: 311.425
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-12 11:59:50
- Modify Date: 2024-01-12 07:14:21
-
NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.
| Name | NITD-916 |
|---|
| Description | NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb; shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket; shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. |
|---|---|
| References | References 1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3. 2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136. View Related Products by Target Bacterial |
| Molecular Formula | C20H25NO2 |
|---|---|
| Molecular Weight | 311.425 |