1621332-91-9
1621332-91-9 structure
- Name: SF0166
- Chemical Name: SF0166
- CAS Number: 1621332-91-9
- Molecular Formula: C23H27F2N5O4
- Molecular Weight: 475.497
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2020-01-20 11:15:57
- Modify Date: 2024-01-02 20:36:00
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SF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8; inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 of 7.6 pM-76 nM; significantly decreases neovascularization in the oxygen-induced retinopathy mouse models. Other Indication Phase 2 Clinical
| Name | SF0166 |
|---|
| Description | SF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8; inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 of 7.6 pM-76 nM; significantly decreases neovascularization in the oxygen-induced retinopathy mouse models. Other Indication Phase 2 Clinical |
|---|---|
| References | References 1. Askew BC, et al. J Pharmacol Exp Ther. 2018 May 31. pii: jpet.118.248427. View Related Products by Target Integrin Other Indication |
| Molecular Formula | C23H27F2N5O4 |
|---|---|
| Molecular Weight | 475.497 |