1841409-92-4
1841409-92-4 structure
- Name: SH-BC-893
- Chemical Name: SH-BC-893
- CAS Number: 1841409-92-4
- Molecular Formula: C19H32ClNO
- Molecular Weight: 325.921
- Catalog: Research Areas Cancer
- Create Date: 2020-01-14 16:53:29
- Modify Date: 2024-01-02 17:41:15
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SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve; selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo.
| Name | SH-BC-893 |
|---|
| Description | SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve; selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo. |
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| References | References 1. Kim SM, et al. J Clin Invest. 2016 Nov 1;126(11):4088-4102. View Related Products by Target Other Targets |
| Molecular Formula | C19H32ClNO |
|---|---|
| Molecular Weight | 325.921 |