1894207-44-3
1894207-44-3 structure
- Name: KDS2010
- Chemical Name: KDS2010
- CAS Number: 1894207-44-3
- Molecular Formula: C17H17F3N2O
- Molecular Weight: 322.331
- Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
- Create Date: 2020-01-20 10:17:57
- Modify Date: 2024-01-09 15:50:54
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KDS2010 (KDS-2010, KDS 2010) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM; displays 12,500-fold selectivity over MAO-A; shows a marked enantiomer selectivity (eightfold selectivity) over the (R)-isomer; significantly ameliorates the impairments in spike probability, learning, and memory in APP/PS1 mice, but not by selegiline, also reverses spatial learning and memory impairments in the Morris water maze test.
| Name | KDS2010 |
|---|
| Description | KDS2010 (KDS-2010, KDS 2010) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM; displays 12,500-fold selectivity over MAO-A; shows a marked enantiomer selectivity (eightfold selectivity) over the (R)-isomer; significantly ameliorates the impairments in spike probability, learning, and memory in APP/PS1 mice, but not by selegiline, also reverses spatial learning and memory impairments in the Morris water maze test. |
|---|---|
| References | References 1. Park JH, et al. Sci Adv. 2019 Mar 20;5(3):eaav0316. doi: 10.1126/sciadv.aav0316. View Related Products by Target Monoamine Oxidase (MAO) |
| Molecular Formula | C17H17F3N2O |
|---|---|
| Molecular Weight | 322.331 |