2071209-49-7
2071209-49-7 structure
- Name: CAD-031
- Chemical Name: CAD-031
- CAS Number: 2071209-49-7
- Molecular Formula: C18H14F6N2O2
- Molecular Weight: 404.312
- Catalog: Signaling Pathways Neuronal Signaling Dopamine Transporter
- Create Date: 2020-01-10 11:17:19
- Modify Date: 2024-02-29 05:47:57
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CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs); also stimulates the division of NPCs in the subventricular zone of old APPswe/PS1ΔE9 mice; rescues primary cortical neurons from oxytosis, and effectively reduce oxidative stress with EC50 of 20 nM; also prevents loss of energy metabolism that leads to neuron cell death in an in vitro ischemia model with EC50 of 47 nM; target fatty acid metabolism and inflammation, exhibits therapeutic efficacy on cognitive and physiological parameters in mouse model of AD .
| Name | CAD-031 |
|---|
| Description | CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs); also stimulates the division of NPCs in the subventricular zone of old APPswe/PS1ΔE9 mice; rescues primary cortical neurons from oxytosis, and effectively reduce oxidative stress with EC50 of 20 nM; also prevents loss of energy metabolism that leads to neuron cell death in an in vitro ischemia model with EC50 of 47 nM; target fatty acid metabolism and inflammation, exhibits therapeutic efficacy on cognitive and physiological parameters in mouse model of AD . |
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| References | References 1. Daugherty D, et al. Alzheimers Res Ther. 2017 Jul 14;9(1):50. View Related Products by Target Other Targets |
| Molecular Formula | C18H14F6N2O2 |
|---|---|
| Molecular Weight | 404.312 |