2170405-10-2
2170405-10-2 structure
- Name: NLX-204
- Chemical Name: NLX-204
- CAS Number: 2170405-10-2
- Molecular Formula: C20H22ClF2N3O2
- Molecular Weight: 409.862
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-20 07:38:55
- Modify Date: 2024-04-05 20:37:03
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NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pEC50 of 9.37; shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
| Name | NLX-204 |
|---|
| Description | NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pEC50 of 9.37; shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test. |
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| References | References 1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062. View Related Products by Target Histamine Receptor |
| Molecular Formula | C20H22ClF2N3O2 |
|---|---|
| Molecular Weight | 409.862 |