823828-18-8
823828-18-8 structure
- Name: STAT3 inhibitor C188
- Chemical Name: STAT3 inhibitor C188
- CAS Number: 823828-18-8
- Molecular Formula: C19H15NO7S2
- Molecular Weight: 433.449
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2020-01-11 15:52:49
- Modify Date: 2024-04-08 12:06:09
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A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3; inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM, induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation.
| Name | STAT3 inhibitor C188 |
|---|
| Description | A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3; inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM, induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation. |
|---|---|
| References | References 1. Xu X, et al. PLoS One. 2009;4(3):e4783. View Related Products by Target STAT |
| Molecular Formula | C19H15NO7S2 |
|---|---|
| Molecular Weight | 433.449 |