906737-25-5
906737-25-5 structure
- Name: ASP 8477
- Chemical Name: ASP 8477
- CAS Number: 906737-25-5
- Molecular Formula: C18H19N3O3
- Molecular Weight: 325.368
- Create Date: 2020-01-20 01:30:56
- Modify Date: 2024-07-18 18:59:03
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A novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively; displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL; elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p.o). Pain Phase 2 Discontinued
| Name | ASP 8477 |
|---|
| Description | A novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively; displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL; elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p.o). Pain Phase 2 Discontinued |
|---|---|
| References | References 1. Watabiki T, et al. Eur J Pharmacol. 2017 Nov 15;815:42-48. 2. Bradford D, et al. Pain Med. 2017 Dec 1;18(12):2388-2400. View Related Products by Target FAAH Pain |
| Molecular Formula | C18H19N3O3 |
|---|---|
| Molecular Weight | 325.368 |