1899921-05-1
1899921-05-1 structure
- Name: HS-10296
- Chemical Name: HS-10296
- CAS Number: 1899921-05-1
- Molecular Formula: C30H36ClN7O2
- Molecular Weight: 562.11
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2020-01-11 20:22:49
- Modify Date: 2024-01-09 21:21:34
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HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity.
| Name | HS-10296 |
|---|
| Description | HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. |
|---|---|
| In Vitro | An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. |
| Molecular Formula | C30H36ClN7O2 |
|---|---|
| Molecular Weight | 562.11 |
| Storage condition | -20℃ |