1402057-88-8

1402057-88-8 structure

1402057-88-8 structure

Name: Cdc7-IN-6
Chemical Name: Cdc7-IN-6
CAS Number: 1402057-88-8
Molecular Formula: C₂₁H₂₂F₃N₅O₄
Molecular Weight: 465.43
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-01-23 23:47:51
Modify Date: 2024-01-08 23:05:30
Cdc7-IN-6 (compound I-D) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1].

Name	Cdc7-IN-6

Description	Cdc7-IN-6 (compound I-D) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
In Vitro	Cdc7-IN-6 demonstrates potent inhibitory activity (IC50<3 µΜ) in a range of solid tumor cell lines, including those of bladder (5673, RT1 12/84), sarcoma (143B, CADO-ES1, RD-ES, A673), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), head-and-neck (CNE-2Z, RPMI-2650), melanoma (A2058, A875), and gastric (HGC-27) lineages[1].
References	[1]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.

Molecular Formula	C₂₁H₂₂F₃N₅O₄
Molecular Weight	465.43