1354787-76-0

1354787-76-0 structure

Name: DC44SMe
Chemical Name: DC44SMe
CAS Number: 1354787-76-0
Molecular Formula: C₃₈H₃₇ClN₅O₇PS₂
Molecular Weight: 806.29
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2020-01-23 19:29:51
Modify Date: 2025-11-24 20:31:04
DC44SMe, a phosphate prodrug of cytotoxic DNA alkylator DC44, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer[1].

Name	DC44SMe

Description	DC44SMe, a phosphate prodrug of cytotoxic DNA alkylator DC44, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
In Vitro	The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability[1].
References	[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

Molecular Formula	C₃₈H₃₇ClN₅O₇PS₂
Molecular Weight	806.29