1147271-25-7

1147271-25-7 structure

Name: 2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
Chemical Name: 2-Amino-8-(2-morpholin-4-yl-ethoxy)-4-phenyl-indeno[1,2-d]pyrimidin-5-one
CAS Number: 1147271-25-7
Molecular Formula: C₂₃H₂₂N₄O₃
Molecular Weight: 402.45
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-12-01 04:21:05
Modify Date: 2024-01-31 23:40:04
JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].

Name	2-Amino-8-(2-morpholin-4-yl-ethoxy)-4-phenyl-indeno[1,2-d]pyrimidin-5-one

Description	JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
In Vivo	JNJ-40255293 (0.1-10 mg/kg, p.o.) 可以逆转氟哌啶醇 (HY-14538) 诱导的雄性 Balb/c 小鼠僵直症。在雄性 Wistar 大鼠中，JNJ-40255293 也可以剂量依赖性地逆转氟哌啶醇（0.63 mg/kg，皮下注射）诱导的强直性昏厥，增强主动觉醒，显着逆转利血平(HY-N0480)引起的运动活性缺陷[1]。
References	[1]. John R Atack, et al. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19.