174362-95-9

174362-95-9 structure

Name: Amino-Tri-(carboxyethoxymethyl)-methane
Chemical Name: Amino-Tri-(carboxyethoxymethyl)-methane
CAS Number: 174362-95-9
Molecular Formula: C₁₃H₂₃NO₉
Molecular Weight: 337.32
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2020-04-13 12:57:56
Modify Date: 2024-01-03 10:23:27
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	Amino-Tri-(carboxyethoxymethyl)-methane

Description	Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2. [2]. David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.