185022-12-2

185022-12-2 structure

Name: Aminooxy-PEG2-alcohol
Chemical Name: Aminooxy-PEG2-alcohol
CAS Number: 185022-12-2
Molecular Formula: C₄H₁₁NO₃
Molecular Weight: 121.14
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2020-04-09 07:38:51
Modify Date: 2024-02-02 14:36:30
Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	Aminooxy-PEG2-alcohol

Description	Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2. [2]. Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3.