2246956-84-1
2246956-84-1 structure
- Name: CDK9-IN-9
- Chemical Name: CDK9-IN-9
- CAS Number: 2246956-84-1
- Molecular Formula: C22H23F2N5O2S
- Molecular Weight: 459.51
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-04-07 12:11:50
- Modify Date: 2024-01-10 17:27:16
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CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1].
| Name | CDK9-IN-9 |
|---|
| Description | CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK9:1.8 nM (IC50) CDK2:155 nM (IC50) |
| In Vitro | CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively[1]. |
| References |
[1]. Ulrich LÜCKING, et al. Novel ptefb inhibiting macrocyclic compounds. WO2018177889A1. |
| Molecular Formula | C22H23F2N5O2S |
|---|---|
| Molecular Weight | 459.51 |