2378114-72-6
2378114-72-6 structure
- Name: Lanreotide acetate
- Chemical Name: Lanreotide acetate
- CAS Number: 2378114-72-6
- Molecular Formula: C56H73N11O12S2
- Molecular Weight: 1156.38
- Catalog: Research Areas Cancer
- Create Date: 2020-04-05 17:44:17
- Modify Date: 2024-01-06 19:08:41
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Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for carcinoid syndrome[1][2].
| Name | Lanreotide acetate |
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| Description | Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for carcinoid syndrome[1][2]. |
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| Related Catalog | |
| In Vitro | Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion[1]. Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM[1]. Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro[2]. |
| In Vivo | Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition[1]. Animal Model: Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)[1] Dosage: 2.5, 5, 10 mg/kg Administration: Subcutaneous; daily for 5 days Result: Produced tumor growth inhibition. |
| References |
| Molecular Formula | C56H73N11O12S2 |
|---|---|
| Molecular Weight | 1156.38 |