180608-78-0

180608-78-0 structure

Name: N-(5-Hydroxypentyl)maleimide
Chemical Name: N-(5-Hydroxypentyl)maleimide
CAS Number: 180608-78-0
Molecular Formula: C₉H₁₃NO₃
Molecular Weight: 183.20
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2020-04-06 19:27:30
Modify Date: 2024-01-15 17:40:51
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

Name	N-(5-Hydroxypentyl)maleimide

Description	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].
References	[1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.