1384984-20-6
1384984-20-6 structure
- Name: pVXc-486
- Chemical Name: pVXc-486
- CAS Number: 1384984-20-6
- Molecular Formula: C21H24FN6Na2O6P
- Molecular Weight: 552.40
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-04-08 19:22:50
- Modify Date: 2024-01-15 14:09:55
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pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1].
| Name | pVXc-486 |
|---|
| Description | pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1]. |
|---|---|
| Related Catalog | |
| In Vivo | pVXc-486 (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1]. pVXc-486 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1]. Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1] Dosage: 10, 30, 100 mg/kg Administration: Oral gavage; 5 times per week for 4 weeks Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice. |
| References |
| Molecular Formula | C21H24FN6Na2O6P |
|---|---|
| Molecular Weight | 552.40 |