534605-74-8
534605-74-8 structure
- Name: TP3011
- Chemical Name: TP3011
- CAS Number: 534605-74-8
- Molecular Formula: C26H26N4O5
- Molecular Weight: 474.51
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2020-04-08 17:28:29
- Modify Date: 2024-01-12 17:43:36
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TP3011 is a potent topoisomerase-1 inhibitor and is the active metabolite converted from TP3076 by aldehyde oxidase 1 (AOX1)[1]. TP3011 has robust anti-tumor activities against cancer cell lines[2].
| Name | TP3011 |
|---|
| Description | TP3011 is a potent topoisomerase-1 inhibitor and is the active metabolite converted from TP3076 by aldehyde oxidase 1 (AOX1)[1]. TP3011 has robust anti-tumor activities against cancer cell lines[2]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | TP3011 (0-100 nM; 72 hours) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively[2]. Cell Proliferation Assay[2] Cell Line: HCT116, QG56, and NCI-H460 (NSCLC) cells Concentration: 0-100 nM Incubation Time: 72 hours Result: Was against human cancer cell lines, such as CRC and NSCLC cell lines. |
| References |
| Molecular Formula | C26H26N4O5 |
|---|---|
| Molecular Weight | 474.51 |