511514-03-7

511514-03-7 structure

511514-03-7 structure

Name: 0990CL
Chemical Name: 0990CL
CAS Number: 511514-03-7
Molecular Formula: C₂₁H₂₁N₅
Molecular Weight: 343.42
Catalog: Research Areas Others
Create Date: 2020-06-01 22:41:58
Modify Date: 2025-08-27 05:53:36
0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP[1].

Name	0990CL

Description	0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	IC50: Gαi subunit[1]
In Vitro	0990CL (100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP[1]. 0990CL (30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively[1].
References	[1]. Appleton KM,et al. Development of inhibitors of heterotrimeric Gαi subunits.Bioorg Med Chem. 2014 Jul 1;22(13):3423-34.

Molecular Formula	C₂₁H₂₁N₅
Molecular Weight	343.42

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