2412923-79-4
2412923-79-4 structure
- Name: Aniline-MPB-amino-C3-PBD
- Chemical Name: Aniline-MPB-amino-C3-PBD
- CAS Number: 2412923-79-4
- Molecular Formula: C42H46N8O6
- Molecular Weight: 758.86
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-06-01 18:57:20
- Modify Date: 2025-08-23 19:15:48
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Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].
| Name | Aniline-MPB-amino-C3-PBD |
|---|
| Description | Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Pyrrolobenzodiazepines |
| In Vitro | Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1]. |
| References |
[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1. |
| Molecular Formula | C42H46N8O6 |
|---|---|
| Molecular Weight | 758.86 |