2412923-79-4

2412923-79-4 structure

Name: Aniline-MPB-amino-C3-PBD
Chemical Name: Aniline-MPB-amino-C3-PBD
CAS Number: 2412923-79-4
Molecular Formula: C₄₂H₄₆N₈O₆
Molecular Weight: 758.86
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-06-01 18:57:20
Modify Date: 2024-01-04 18:39:51
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

Name	Aniline-MPB-amino-C3-PBD

Description	Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Anti-infection >> Bacterial
Target	Pyrrolobenzodiazepines
In Vitro	Aniline-MPB-amino-C3-PBD (compound 16) shows cytotoxicity with IC50s of 77, 72, 79, 184.3, 61.5, and 145.6 nM for SW48, LIM1215, SW620, U138-MG, A431, and REH cells, respectively. Aniline-MPB-amino-C3-PBD effectively stabilises DNA with a degree of sequence-specificity. Aniline-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12 with potency of 2 pg/mL determined[1].
References	[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

Molecular Formula	C₄₂H₄₆N₈O₆
Molecular Weight	758.86