2414373-55-8
2414373-55-8 structure
- Name: CDK6/9-IN-1
- Chemical Name: CDK6/9-IN-1
- CAS Number: 2414373-55-8
- Molecular Formula: C22H25ClN8O
- Molecular Weight: 452.94
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-06-01 16:47:22
- Modify Date: 2024-01-09 14:29:35
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CDK6/9-IN-1 (compound 66) is an oral available and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].
| Name | CDK6/9-IN-1 |
|---|
| Description | CDK6/9-IN-1 (compound 66) is an oral available and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK6:40.5 nM (IC50) CDK9:39.5 nM (IC50) |
| In Vitro | CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)[1]. |
| In Vivo | CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1]. |
| References |
| Molecular Formula | C22H25ClN8O |
|---|---|
| Molecular Weight | 452.94 |