2228857-36-9

2228857-36-9 structure

2228857-36-9 structure

Name: M-PEG4-DBCO
Chemical Name: m-PEG4-NH-DBCO
CAS Number: 2228857-36-9
Molecular Formula: C₂₈H₃₄N₂O₆
Molecular Weight: 494.58
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-02 01:31:46
Modify Date: 2024-01-04 19:10:12
m-PEG4-NH-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	m-PEG4-NH-DBCO
Synonyms	MFCD31654033

Description	m-PEG4-NH-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₈H₃₄N₂O₆
Molecular Weight	494.58