2353409-63-7

2353409-63-7 structure

2353409-63-7 structure

Name: 1-(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl)-1H-pyrrole-2,5-dione
Chemical Name: Mal-PEG8-alcohol
CAS Number: 2353409-63-7
Molecular Formula: C₂₀H₃₅NO₁₀
Molecular Weight: 449.49
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 14:24:12
Modify Date: 2024-01-24 18:44:23
Mal-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Mal-PEG8-alcohol
Synonyms	MFCD31811461

Description	Mal-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₀H₃₅NO₁₀
Molecular Weight	449.49