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2112738-60-8

2112738-60-8 structure
2112738-60-8 structure
  • Name: N-Mal-N-bis(PEG4-NHS ester)
  • Chemical Name: N-Mal-N-bis(PEG4-NHS ester)
  • CAS Number: 2112738-60-8
  • Molecular Formula: C37H54N4O19
  • Molecular Weight: 858.84
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2020-06-01 12:47:21
  • Modify Date: 2024-01-10 22:43:19
  • N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name N-Mal-N-bis(PEG4-NHS ester)
Synonyms MFCD29912654
Description N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C37H54N4O19
Molecular Weight 858.84