2098621-90-8

2098621-90-8 structure

Name: Protein kinase affinity probe 1
Chemical Name: Protein kinase affinity probe 1
CAS Number: 2098621-90-8
Molecular Formula: C₂₆H₃₉ClN₈O₂
Molecular Weight: 531.09
Catalog: Research Areas Others
Create Date: 2020-06-01 14:47:44
Modify Date: 2024-01-01 18:31:02
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3)[1].

Name	Protein kinase affinity probe 1

Description	Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	“S” indicates that the PKI (Purvalanol B) is sepharose-bound[1]. In a series of pull-down experiments from the lysates of HeLa cells, the effects of 0.1, 0.5, 1, 2, 5, 10, 25, and 50% loadings of PK inhibitors is determined. Examine higher bead loadings (75 and 100%) are prevented due to lack of compound solubility and poor reproducibility of the synthesis outcomes. 50% loading is the highest feasible in this study[1].
References	[1]. Deane FM, et al. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838.

Molecular Formula	C₂₆H₃₉ClN₈O₂
Molecular Weight	531.09