2115897-23-7

2115897-23-7 structure

Name: (S,S,S)-AHPC hydrochloride
Chemical Name: (S,S,S)-AHPC hydrochloride
CAS Number: 2115897-23-7
Molecular Formula: C₂₂H₃₁ClN₄O₃S
Molecular Weight: 467.02
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2020-06-01 23:07:46
Modify Date: 2024-01-05 05:59:34
(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

Name	(S,S,S)-AHPC hydrochloride

Description	(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	VHL
In Vitro	The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
References	[1]. Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598.