2353409-48-8

2353409-48-8 structure

Name: 1-(3-(Dimethylamino)propyl)-3-ethylurea 1-((3-(2-(2-(((cyclooct-4-en-1-yloxy)carbonyl)amino)ethoxy)ethoxy)propanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate
Chemical Name: TCO-PEG2-Sulfo-NHS ester
CAS Number: 2353409-48-8
Molecular Formula: C₂₈H₄₉N₅O₁₂S
Molecular Weight: 679.78
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 12:44:18
Modify Date: 2023-01-17 09:36:08
TCO-PEG2-Sulfo-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	TCO-PEG2-Sulfo-NHS ester

Description	TCO-PEG2-Sulfo-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₈H₄₉N₅O₁₂S
Molecular Weight	679.78