2411681-89-3

2411681-89-3 structure

2411681-89-3 structure

Name: Thalidomide-O-amido-PEG4-azide
Chemical Name: Thalidomide-O-amido-PEG4-azide
CAS Number: 2411681-89-3
Molecular Formula: C₂₅H₃₂N₆O₁₀
Molecular Weight: 576.56
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 17:55:22
Modify Date: 2024-01-09 15:02:29
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-PEG4-azide
Synonyms	MFCD32670309

Description	Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₅H₃₂N₆O₁₀
Molecular Weight	576.56