1402086-20-7

1402086-20-7 structure

Name: Afatinib impurity 11
Chemical Name: Afatinib impurity 11
CAS Number: 1402086-20-7
Molecular Formula: C₂₁H₁₈ClFN₄O₃
Molecular Weight: 428.84
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2020-08-11 18:08:48
Modify Date: 2024-01-14 09:48:58
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

Name	Afatinib impurity 11

Description	Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

Molecular Formula	C₂₁H₁₈ClFN₄O₃
Molecular Weight	428.84