2240191-12-0
2240191-12-0 structure
- Name: BCR-ABL-IN-3
- Chemical Name: BCR-ABL-IN-3
- CAS Number: 2240191-12-0
- Molecular Formula: C20H17ClF2N4O3S
- Molecular Weight: 466.89
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2020-08-11 10:46:38
- Modify Date: 2024-01-02 18:24:19
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BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].
| Name | BCR-ABL-IN-3 |
|---|
| Description | BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Ba/F3Bcr-AblT3151:≤100 nM (IC50) |
| In Vivo | BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F3Bcr-AblT3151 cells[1]. BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a Cmax of 5485 ng/mL and an AUC of 5450 h•ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g[1]. |
| References |
| Molecular Formula | C20H17ClF2N4O3S |
|---|---|
| Molecular Weight | 466.89 |