2416021-47-9
2416021-47-9 structure
- Name: DDR1-IN-6
- Chemical Name: DDR1-IN-6
- CAS Number: 2416021-47-9
- Molecular Formula: C23H14F3N5O
- Molecular Weight: 433.39
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Discoidin Domain Receptor
- Create Date: 2020-08-08 20:41:19
- Modify Date: 2024-01-11 09:33:22
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DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1].
| Name | DDR1-IN-6 |
|---|
| Description | DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
DDR1:9.72 nM (IC50) |
| In Vitro | DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM)[1]. DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM)[1]. DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days)[1]. |
| References |
[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1. |
| Molecular Formula | C23H14F3N5O |
|---|---|
| Molecular Weight | 433.39 |