1450595-86-4
1450595-86-4 structure
- Name: DS-1971a
- Chemical Name: DS-1971a
- CAS Number: 1450595-86-4
- Molecular Formula: C20H21ClFN5O3S
- Molecular Weight: 465.93
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2020-08-11 18:08:34
- Modify Date: 2024-01-02 16:49:27
-
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1].
| Name | DS-1971a |
|---|
| Description | DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 22.8 nM (hNaV1.7), 59.4 nM (mNaV1.7)[1] |
| In Vivo | DS-1971a exhibits a favorable toxicological profile[1]. DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice[1]. Animal Model: Male Slc:ddY mice (PSL model)[1] Dosage: 0.1, 0.3, and 1 mg/kg Administration: P.o. Result: A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg. |
| References |
| Molecular Formula | C20H21ClFN5O3S |
|---|---|
| Molecular Weight | 465.93 |