- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: ELA-14 (human) TFA
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
1886973-05-2
1886973-05-2 structure
- Name: ELA-14 (human) TFA
- Chemical Name: Elabela(19-32)
- CAS Number: 1886973-05-2
- Molecular Formula: C75H119N25O17S2
- Molecular Weight: 1707.03
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-08-11 16:24:18
- Modify Date: 2024-01-14 17:10:12
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Elabela(19-32) is a potent apelin receptor (APJ) endogenous agonist with a Ki of 0.93 nM. Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1][2].
| Name | Elabela(19-32) |
|---|
| Description | Elabela(19-32) is a potent apelin receptor (APJ) endogenous agonist with a Ki of 0.93 nM. Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1][2]. |
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| Related Catalog | |
| Target |
Ki: 0.93 nM (APJ)[1] IC50: 8.6 nM (Gαi1) and 166 nM (β-arrestin-2)[1] |
| In Vitro | Elabela(19-32) (analogue 3) has an EC50 of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) is slightly less potent than apelin-13 and ELA to elicit receptor internalization[1]. Elabela(19-32) (0.001 to 0.3 nM) has an EC50 of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart[1]. |
| In Vivo | Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t1/2<2 min)[1]. |
| References |
| Molecular Formula | C75H119N25O17S2 |
|---|---|
| Molecular Weight | 1707.03 |