1883548-93-3
1883548-93-3 structure
- Name: Mps1-IN-1 dihydrochloride
- Chemical Name: Mps1-IN-1 dihydrochloride
- CAS Number: 1883548-93-3
- Molecular Formula: C28H35Cl2N5O4S
- Molecular Weight: 608.58
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Mps1
- Create Date: 2020-08-08 10:19:19
- Modify Date: 2024-03-06 12:32:11
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Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1].
| Name | Mps1-IN-1 dihydrochloride |
|---|
| Description | Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
Mps1:27 nM (Kd) ALK:21 nM (Kd) LTK:29 nM (Kd) PYK2:280 nM (Kd) FAK:440 nM (IC30) IGF1R:750 nM (Kd) INSR:470 nM (Kd) CLK1:1900 nM (Kd) ERK2:2900 nM (Kd) INSRR:1200 nM (Kd) TNK1:2600 nM (Kd) TNK2:3100 nM (Kd) GAK:1100 nM (Kd) Mps1:367 nM (IC50) |
| In Vitro | Mps1-IN-1 dihydrochloride is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM. Mps1-IN-1 dihydrochloride also has high affinity for ALK, and LTK, with Kds of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 dihydrochloride (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 dihydrochloride (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 dihydrochloride (5-10 µM) suppresses the proliferative capacity of HCT116[1]. |
| References |
| Molecular Formula | C28H35Cl2N5O4S |
|---|---|
| Molecular Weight | 608.58 |