356783-08-9
356783-08-9 structure
- Name: T-705RMP
- Chemical Name: T-705RMP
- CAS Number: 356783-08-9
- Molecular Formula: C10H13FN3O9P
- Molecular Weight: 369.20
- Catalog: Research Areas Infection
- Create Date: 2020-08-10 21:13:52
- Modify Date: 2024-01-02 16:32:39
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T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM[1].
| Name | T-705RMP |
|---|
| Description | T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM[1]. |
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| Related Catalog | |
| In Vitro | T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme[1]. |
| References |
| Molecular Formula | C10H13FN3O9P |
|---|---|
| Molecular Weight | 369.20 |