2360530-43-2

2360530-43-2 structure

Name: Thalidomide-NH-PEG3-CH2CHO
Chemical Name: Thalidomide-NH-PEG3-CH2CHO
CAS Number: 2360530-43-2
Molecular Formula: C₂₁H₂₅N₃O₈
Molecular Weight: 447.44
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2020-08-07 18:37:58
Modify Date: 2024-02-29 03:27:37
Thalidomide-NH-PEG3-CH2CHO is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-PEG3-CH2CHO can be connected to the ligand for protein by a linker to form PROTAC BCL-XL degrader XZ739 (HY-133557)[1].

Name	Thalidomide-NH-PEG3-CH2CHO

Description	Thalidomide-NH-PEG3-CH2CHO is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-PEG3-CH2CHO can be connected to the ligand for protein by a linker to form PROTAC BCL-XL degrader XZ739 (HY-133557)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
References	[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Molecular Formula	C₂₁H₂₅N₃O₈
Molecular Weight	447.44