901787-88-0
901787-88-0 structure
- Name: (Z)-4EGI-1
- Chemical Name: (Z)-4EGI-1
- CAS Number: 901787-88-0
- Molecular Formula: C18H12Cl2N4O4S
- Molecular Weight: 451.28
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
- Create Date: 2020-08-08 16:58:19
- Modify Date: 2024-01-11 18:37:52
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(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].
| Name | (Z)-4EGI-1 |
|---|
| Description | (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 43.5 μM (eIF4E)[2] Kd: 8.74 μM (eIF4E)[1] |
| In Vitro | (Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected[1]. (Z)-4EGI-1 inhibits cancer cells proliferation with IC50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively[2]. Western Blot Analysis[1] Cell Line: CRL-2813 melanoma cells Concentration: 15 µM, 30 µM Incubation Time: 6 hours Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. |
| References |
| Molecular Formula | C18H12Cl2N4O4S |
|---|---|
| Molecular Weight | 451.28 |