1486482-16-9

1486482-16-9 structure

Name: ML251
Chemical Name: 2-(3,4-Dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide
CAS Number: 1486482-16-9
Molecular Formula: C₁₇H₁₃Cl₂N₃O₄S
Molecular Weight: 426.27
Catalog: Research Areas Infection
Create Date: 2021-01-20 15:38:42
Modify Date: 2024-09-16 13:00:19
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

Name	2-(3,4-Dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide
Synonyms	Benzeneacetamide, 3,4-dichloro-N-[4-[(3-isoxazolylamino)sulfonyl]phenyl]-

Description	ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 0.37 μM (T. brucei PFK)[1]. IC50: 0.13 μM (T. cruzi PFK)[1]
In Vitro	ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. Cell Cytotoxicity Assay[1] Cell Line: T. brucei Concentration: 0~33.3 μg/mL Incubation Time: Result: Dose-dependent reduction of cell viability.
References	[1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.