1431540-99-6

1431540-99-6 structure

Name: TC KHNS 11
Chemical Name: 5-(4-{3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl}-6-quinazolinyl)-2-methoxynicotinonitrile
CAS Number: 1431540-99-6
Molecular Formula: C₂₈H₂₄N₆O₃
Molecular Weight: 492.53
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2021-01-09 21:26:56
Modify Date: 2025-08-22 18:50:13
PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties[1].

Name	5-(4-{3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl}-6-quinazolinyl)-2-methoxynicotinonitrile
Synonyms	MFCD31689242 3-Pyridinecarbonitrile, 5-[4-[3-[(4-acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy- 5-{4-[3-(4-Acetylpiperazine-1-Carbonyl)phenyl]quinazolin-6-Yl}-2-Methoxypyridine-3-Carbonitrile 5-(4-{3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl}-6-quinazolinyl)-2-methoxynicotinonitrile

Description	PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	9 nM, 0.262 μM, 1.65 μM, 4.63 μM (PI3Kδ, PI3Kα, PI3Kβ, PI3Kγ)[1]
References	[1]. Hoegenauer K, et al. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2016 Jun 2;7(8):762-7.