51744-55-9

51744-55-9 structure

Name: Purpurin 18 methyl ester
Chemical Name: Methyl 3-[(10Z,14Z,20Z,22S)-12-ethyl-13,18,22,27-tetramethyl-3,5-dioxo-17-vinyl-4-oxa-8,24,25,26-tetraazahexacyclo[19.2.1.16,9.111,14.116,19.02,7]heptacosa-1(23),2(7),6(27),8,10,12,14,16,18,20-decaen-23-yl]propanoate
CAS Number: 51744-55-9
Molecular Formula: C₃₄H₃₄N₄O₅
Molecular Weight: 578.658
Catalog: Signaling Pathways Others Others
Create Date: 2021-01-07 19:21:03
Modify Date: 2024-01-03 21:21:32
Purpurin 18 methyl ester, a chlorophyll-a derivative, and is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death[1].

Name	Methyl 3-[(10Z,14Z,20Z,22S)-12-ethyl-13,18,22,27-tetramethyl-3,5-dioxo-17-vinyl-4-oxa-8,24,25,26-tetraazahexacyclo[19.2.1.16,9.111,14.116,19.02,7]heptacosa-1(23),2(7),6(27),8,10,12,14,16,18,20-decaen-23-yl]propanoate
Synonyms	Methyl 3-[(10Z,14Z,20Z,22S)-12-ethyl-13,18,22,27-tetramethyl-3,5-dioxo-17-vinyl-4-oxa-8,24,25,26-tetraazahexacyclo[19.2.1.16,9.111,14.116,19.02,7]heptacosa-1(23),2(7),6(27),8,10,12,14,16,18,20 -decaen-23-yl]propanoate

Description	Purpurin 18 methyl ester, a chlorophyll-a derivative, and is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Purpurin 18 methyl ester (1-5 μg/mL; 24 h) has no cytotoxicity in dark in HepG-2 cells[1]. Purpurin 18 methyl ester (1-5 μg/mL; 24 h) decreases the viability of HepG-2 cells in a concentration-dependent manner with irradiation for 10 min[1]. Purpurin 18 methyl ester (0-24 h) is released from GO- Purpurin 18 methyl ester (Pu18) composite, with rates of 47%, 22% and 30% in weak acidic condition (pH 5.6), neutral environment (pH 7.4) and weak alkali condition (pH 8.9) for 24 h, respectively[1].
References	[1]. Zhang Y, et, al. pH-Sensitive graphene oxide conjugate Purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy. New Journal of Chemistry. 2018 Jun 26; 42(16):13272-13284.