286369-38-8

286369-38-8 structure

Name: S 14506 hydrochloride
Chemical Name: S 14506 hydrochloride
CAS Number: 286369-38-8
Molecular Formula: C₂₄H₂₇ClFN₃O₂
Molecular Weight: 443.941
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2021-05-12 12:52:30
Modify Date: 2025-08-25 09:35:01
S-14506 hydrochloride is a potent 5-HT1A agonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2].

Name	S 14506 hydrochloride
Synonyms	S-14506 HYDROCHLORIDE 4-Fluoro-N-{2-[4-(7-methoxy-1-naphthyl)-1-piperazinyl]ethyl}benzamide hydrochloride (1:1) MFCD00910294 Benzamide, 4-fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:1) 4-Fluoro-N-{2-[4-(7-methoxy-1-naphthyl)piperazin-1-yl]ethyl}benzamide hydrochloride (1:1) 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride

Description	S-14506 hydrochloride is a potent 5-HT1A agonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2].
Related Catalog	Research Areas >> Others Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Francis C. Colpaert, et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. 1992, 21-48. [2]. Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77.