402942-53-4

402942-53-4 structure

Name: DR4485 hydrochloride
Chemical Name: DR 4485 hydrochloride
CAS Number: 402942-53-4
Molecular Formula: C₂₆H₂₉Cl₃N₂O
Molecular Weight: 491.880
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2021-05-14 16:36:37
Modify Date: 2024-01-16 15:05:53
DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14)[1].

Name	DR 4485 hydrochloride
Synonyms	6-Chloro-2a-{4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl}-2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one hydrochloride (1:1) Benz[cd]indol-2(1H)-one, 6-chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydro-, hydrochloride (1:1)

Description	DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT7 Receptor:8.14 (pKi)
In Vitro	DR4485 (MZ54 WT cells; 6 µM or 8 µM) hydrochloride induces autophagy as well as cell death that is diminished by KO of ATG5 and ATG7[2].
References	[1]. Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13(1):61-64. [2]. Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20.