57756-44-2

57756-44-2 structure

Name: WAY 629 hydrochloride
Chemical Name: WAY 629 hydrochloride
CAS Number: 57756-44-2
Molecular Formula: C₁₅H₁₉ClN₂
Molecular Weight: 262.778
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2021-05-16 18:37:29
Modify Date: 2024-09-22 12:34:25
WAY 629 hydrochloride is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 hydrochloride decreases feeding behavior[1][2].

Name	WAY 629 hydrochloride
Synonyms	MFCD06798323 [1,4]Diazepino[6,7,1-jk]carbazole, 1,2,3,4,8,9,10,11-octahydro-, hydrochloride (1:1) 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride (1:1) WAY 629 hydrochloride

Description	WAY 629 hydrochloride is a potent and selective 5-HT2C agonist with EC50s of 426, 260000 nM for 5-HT2C and 5-HT2A, respectively. WAY 629 hydrochloride decreases feeding behavior[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2C Receptor:426 nM (EC50) 5-HT2A Receptor:260000 nM (EC50)
In Vivo	WAY 629 hydrochloride (30 mg/kg; i.p.) 降低大鼠的进食行为[1]。 WAY 629 hydrochloride (30 mg/kg; i.p.) 降低小鼠大脑中 NPY mRNA 的表达[2]。 Animal Model: WT mice[2] Dosage: 21 mg/kg Administration: I.p. Result: Decreased the expression of NPY mRNA.
References	[1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. [2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28.