679839-66-8

679839-66-8 structure

Name: BMS 193885
Chemical Name: BMS 193885
CAS Number: 679839-66-8
Molecular Formula: C₃₆H₄₈N₄O₉
Molecular Weight: 680.79
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2021-05-16 12:30:25
Modify Date: 2024-01-09 18:16:02
BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition[1].

Name	BMS 193885
Synonyms	(2S)-2-Hydroxypropanoic acid - dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1:1) (2S)-2-Hydroxypropanoic acid - dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate (1:1) 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-, dimethyl ester, compd. with (2S)-2-hydroxypropanoic acid (1:1)

Description	BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
References	[1]. Ildiko Antal-Zimanyi, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.