2101958-02-3

2101958-02-3 structure

Name: squarunkin A
Chemical Name: Squarunkin A
CAS Number: 2101958-02-3
Molecular Formula: C₂₅H₃₂F₃N₅O₄
Molecular Weight: 523.55
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2021-05-22 16:46:19
Modify Date: 2024-01-21 08:06:57
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1].

Name	Squarunkin A

Description	Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Target	IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]
In Vitro	Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM 和 0.01 μM) 浓度依赖性地抑制 Src 磷酸化[1]。 Squarunkin A 不靶向其他脂蛋白伴侣的脂蛋白结合位点，如结合 s-戊烯化蛋白的 PDE6d, AIPL1 和 RhoGDI。Squarunkin A 在细胞裂解液中与 UNC119 结合并干扰 Src 激活[1]。
References	[1]. Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186.

Molecular Formula	C₂₅H₃₂F₃N₅O₄
Molecular Weight	523.55