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  • DC Chemicals Limited
  • China
  • Product Name: VCP171
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

1018830-99-3

1018830-99-3 structure
1018830-99-3 structure
  • Name: VCP171
  • Chemical Name: VCP171
  • CAS Number: 1018830-99-3
  • Molecular Formula: C18H12F3NOS
  • Molecular Weight: 347.354
  • Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
  • Create Date: 2021-05-25 20:00:06
  • Modify Date: 2024-01-05 18:29:45
  • VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain[1].

Name VCP171
Synonyms {2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl}(phenyl)methanone
VPC171
{2-amino-4-[3-(trifluoromethyl)phenyl]thiophen-3-yl}(phenyl)methanone
Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-
VCP171
Description VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain[1].
Related Catalog
Target

A1R

In Vivo VCP171 (10 μM) reduces AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in lamina I cells in sham and nerve-injured animals; increases paired pulse ration in cells from sham control animals; is significantly more effective in Lamina II neurons from nerve-injured animals than sham controls[1]. Animal Model: Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)[1] Dosage: 10 μM Administration: 0-30 min Result: Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls.
References

[1]. Imlach WL, et al. A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol Pharmacol. 2015 Sep;88(3):460-8.

Density 1.3±0.1 g/cm3
Boiling Point 507.0±50.0 °C at 760 mmHg
Molecular Formula C18H12F3NOS
Molecular Weight 347.354
Flash Point 260.4±30.1 °C
Exact Mass 347.059174
LogP 5.30
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.599