2361327-08-2

2361327-08-2 structure
2361327-08-2 structure
  • Name: DS44960156
  • Chemical Name: DS44960156
  • CAS Number: 2361327-08-2
  • Molecular Formula: C20H15NO5
  • Molecular Weight: 349.34
  • Catalog: Research Areas Others
  • Create Date: 2021-08-11 17:07:01
  • Modify Date: 2025-09-21 12:15:17
  • DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].

Name DS44960156
Synonyms DS44960156
4-[(5-Oxo-1,5-dihydro-2H-chromeno[3,4-c]pyridin-3(4H)-yl)carbonyl]benzoic acid
Description DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].
Related Catalog
Target

IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1)[1].

References

[1]. Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898.

Density 1.5±0.1 g/cm3
Boiling Point 652.9±55.0 °C at 760 mmHg
Molecular Formula C20H15NO5
Molecular Weight 349.34
Flash Point 348.7±31.5 °C
Exact Mass 349.095032
LogP 2.71
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.700
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.