157000-76-5

157000-76-5 structure

Name: Datelliptium chloride hydrochloride
Chemical Name: Datelliptium chloride hydrochloride
CAS Number: 157000-76-5
Molecular Formula: C₂₃H₂₉Cl₂N₃O
Molecular Weight: 434.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2021-09-11 12:19:54
Modify Date: 2024-01-07 15:37:25
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors[1][2].

Name	Datelliptium chloride hydrochloride

Description	Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes[1].
In Vivo	Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo[2]. Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease[2]. Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210[2]. Animal Model: Mice, colon adenocarcinoma early staged disease model[2] Dosage: 170 mg/kg Administration: Intravenous injection, for 12 days Result: Highly active against colon adenocarcinoma.
References	[1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61.

Molecular Formula	C₂₃H₂₉Cl₂N₃O
Molecular Weight	434.40